Nasal reconstruction on supernumerary nostril: A rare case report.

INTRODUCTION: A supernumerary nostril is one of the rarest congenital nasal abnormalities. Recently we encountered a 16-months-old patient with 3 supernumerary nostrils that was located at left side of the nose and performed an operation on this case. We reported a rare case of three supernumerary nostril located at left side of the nose. CASE PRESENTATION: A 14-month-old male baby was referred to our clinic for assessment of a nose deformity. Physical examination revealed an asymmetrical ala of nose with 3 supernumerary nostrils at left side and a normal right nostril. She was diagnosed with supernumerary rostril and underwent fistulectomy of the accessory nasal tract, followed by nostril reconstruction with primary closure of margin defect at 16-month-old. There was no complication and she was discharged the next day. One month after surgery triamcinolone was injected at scar. Nasal cavity retainer is still maintained in place as aftercare for at least 3-months-post-surgery. We obtained an event-free postoperative result with good function and aesthetic results. DISCUSSION: Supernumerary nostril is an extremely rare case. It should not be confused with a double nose. Surgery should be performed at an early age. Nevertheless, we performed surgery at 16-month-old baby and still obtained satisfying result. CONCLUSION: Surgical technique performed at this rare supernumerary nostril case was fistulectomy of the accessory nasal tract, followed by nostril reconstruction good functions, aesthetic results post operatively.

Management of cutaneous tuberculosis in hand - Rare and disabling: A case report.

INTRODUCTION AND IMPORTANCE: Cutaneous Tuberculosis (CTB), elicited by the Mycobacterium tuberculosis complex, manifests dermatologically. The scarcity of bacilli within CTB lesions renders their detection challenging. This study presents a case of CTB, underscoring its rarity and the potential for severe complications that can deteriorate patient quality of life. It aims to highlight the importance of CTB identification in dermatological diagnoses due to its capacity to cause considerable morbidity and affect patients' psychosocial health. CASE PRESENTATION: An 18-year-old patient presented with a painful, well-defined reddish plaque on the right palm, originating five years prior, accompanied by contractures of the middle finger. The tender lesion, characterized by an irregular surface, exhibited purulent discharge upon light touch through fissures along its periphery. Management involved necrotomy, debridement, and tissue biopsy for diagnostic and reconstructive purposes. CLINICAL DISCUSSION: CTB exhibits a wide range of clinical presentations, often resembling other dermatological infections, which complicates its diagnosis. Accurate diagnosis necessitates an integrated approach involving clinical assessment, the tuberculin skin test, histopathological analysis, and bacteriological investigations. The therapeutic regimen includes multidrug anti-tuberculosis treatment, with surgical intervention reserved for specific cases. CONCLUSION: Long-term complications of untreated CTB encompass significant contractures, scarring, and the onset of carcinomas and sarcomas. Prompt diagnosis facilitates timely and effective treatment, averting these sequelae and yielding high patient satisfaction.

Case report: Remarkable efficacy of negative-pressure wound therapy in giant lower extremity elephantiasis neuromatosa for vascularization, skin grafting, and fluid control.

INTRODUCTION AND IMPORTANCE: Neurofibromatosis type 1 is a benign peripheral nerve tumor, often manifests as plexiform neurofibroma that may cause severe dysfunction, pain, and disfigurement. Bleeding has been reported as a complication of plexiform neurofibroma due to vascular fragility and vasculopathy that may develop into life-threatening bleeding especially after excision procedure. Consequently, post excision complications also include dehiscence and infection. CASE PRESENTATION: We report a 23-year-old male with elephantiasis of the left lower extremity due to giant plexiform neurofibroma who underwent preoperative embolization followed by serial surgical mass reduction. There were postoperative complications consisting of hematoma, wound dehiscence, and infection. CLINICAL DISCUSSION: Negative pressure wound therapy is often used to accelerate wound healing, including infected wounds. However, negative pressure wound therapy has been a debatable modality for wound care of neurofibroma due to reported risks of profuse bleeding during its use. CONCLUSION: In this case, despite the size, negative-pressure wound therapy has shown good results for infected neurofibroma wounds and as an adjunct as wound dressing for defect closure of neurofibroma with split-thickness skin graft.

Enhancing Aesthetic Harmony: Comprehensive Anthropometric Lip Measurements in Youthful and Attractive Indonesian Adults for Precision Cosmetic Procedures.

Lips are an important part of our perception of beauty, youthfulness and attractiveness. Aesthetic lips, as with the rest of the face, differs according to age, ethnicity and sex. The aim of this study was to evaluate the anthropometric measurements of the lips of young and attractive Indonesian adults. Photographs of faces were taken at an anterior neutral position for 100 participants; 47 men and 53 women volunteered to participate in this study. Seven landmarks were used in this study: stomion (st), sublabiale (sl), subnasale (sn), labiale superius (ls), labiale inferius (li), crista philtre (cp) and chelion (ch). Using these landmarks, lower lip height, upper lip height, philtrum length, upper vermillion height, lower vermillion height, cutaneous lower lip height, philtrum width and mouth width were measured. The results were analysed using independent t-test and Mann-Whitney test. Significant differences in lip size were observed between men and women in all the measurements st-sl (lower lip height), sn-st (upper lip height), sn-ls (philtrum length), li-sl (cutaneous lower lip height), sn-ls/ls-st (philtrum length and upper vermillion height) and ls-li/ch-ch (cutaneous lower lip height and mouth width) with a significance of p=0.003, p=0.007, p<0.001, p=0.05, p=0.005 and p=0.021, respectively. Male lip measurements of ch-ch (overall lip width) and ls-st/li-st (overall lower lip height) were significantly smaller than those of female lips. The lip ratios calculated in this study were congruent with aesthetic parameters reported in other populations. This study suggests that the same measurement standards cannot be used on different populations, but these ratios may offer a better framework for precision cosmetic procedures. We believe that the results obtained in this study on lip anthropometry will help in optimising the standard values that can be used for the Indonesian population aged 20 to 35 years.

Pedicled abdominal skin flap technique for fingers salvaging and reconstruction in a complex palmar hand burn injury: A case report.

INTRODUCTION AND IMPORTANCE: The only treatment option for full-thickness burn injury is surgical management, either skin grafting or a skin flap. Treatment may be challenging due to the multiple procedures that need to be performed and multiple factors that can affect treatment outcomes especially to do fingers reconstruction. CASE PRESENTATION: A 25-years-old man was admitted because of a burn injury on the palm of his left hand. There are waxy and leathery appearances of burn injuries on the palm and 2nd to 5th digits of the left hand and diagnosed with a full-thickness contact burn injury and compartment syndrome. The patient underwent a pedicled abdominal skin flap followed by necrotomy, flap thinning, and digit separation as a reconstruction management. CLINICAL DISCUSSION: Pedicled abdominal skin flap is one of the best surgical techniques available for full thickness burn injury reconstruction because it is believed to regain the closest natural-looking appearance and extremity functions. Abdominal flap as random flap is safe to be divided into small part to cover the fingers. CONCLUSION: Thorough examinations and appropriate management such as pedicled abdominal skin flaps are important to perform in patients with full-thickness burn injuries.

Relationship between age and the histopathological features to chemotherapy response in colorectal cancer patients: a prospective observational study

Introduction: Chemotherapy response in early age-onset colorectal cancer patients is still controversial, and the results of chemotherapy response are unknown. Therefore, the purpose of this study is to determine the relationship between the age of colorectal cancer patients and histopathological features and chemotherapy response. Methods: This is a prospective observational study. The subjects in this study were colorectal cancer patients in the Digestive Surgery division at Tertiary Hospital in West Java from September 2021 to September 2022. Results: There were 86 subjects who underwent chemotherapy in accordance with the inclusion and exclusion criteria. Consisting of 39 patients of early age onset and 44 female patients. The most common histopathological feature in early age onset (EAO) and late age onset (LAO) was adenocarcinoma (25% and 46%, respectively). Stage III colorectal cancer affected 38 patients, while stage IV affected 48 patients. There was a significant relationship between early age onset and late age onset with histological features (p < 0.001). The patients with the highest chemotherapy response had stable diseases in EAO (17 patients) and LAO (20 patients). There was no statistically significant relationship between age, histological features, and stage of colorectal cancer and chemotherapy response (p > 0.05). The results of the ordinal logistic regression test showed no systematic relationship between chemotherapy response and age, histopathological features, gender, or cancer stage (p > 0.05). Conclusion: There was no association between age and histopathologic features with chemotherapy response and there is no difference in chemotherapy response between early and late age onset. (AU)

Refining macrostomia correction: Case series applying square flap technique and Z/W-plasty skin closure for enhanced aesthetic and functional outcome.

INTRODUCTION AND IMPORTANCE: Macrostomia is a congenital deformity found in Tessier no. 7 facial clefts defined as an enlargement of the mouth at the oral commissure. Several techniques are described in literature to achieve optimal functional and aesthetic results, with varying results and surgeon preferences. In this case series we report surgical repair of macrostomia with a vermillion square flap method for the oral commissure combined with either Z-plasty or W-plasty closure for the skin. CASES PRESENTATION: A retrospective case analysis of 12 patients with macrostomia operated over the past 7 years at our plastic surgery division was performed (by two different operators; 11 cases by A.S. and 1 case by R.S.). Clinical features of the patients were analyzed through photography documentation, and patient description such as age of operation, operation technique, and complications were obtained through patient records. Macrostomia was corrected with a vermillion square flap method for commissure, overlapping muscle closure, along with either Z-plasty or W-plasty closure for the skin. Quality of lip commissure position, symmetry, thickness of vermillion, and scar result were recorded. CLINICAL DISCUSSION: In all twelve patients repaired with the overlapping muscle closure and square flap, the lip commissures were formed with satisfactory shape, position, and thickness with no commissure contracture during the follow up period. The Z-plasty was a simpler method compared to the W-plasty, and resulted in comparable scars. One patient (adult with hemifacial macrostomia and W-plasty skin closure) underwent revision surgery for more accurate symmetry and position of the oral commissure. CONCLUSION: There are many varieties of surgical repair for macrostomia, and each method should be adjusted and combined according to each patient. Overall, macrostomia repair with this technique combination produced satisfactory aesthetic and functional results in all twelve patients. Z-plasty for skin closure after muscle and vermillion closure was a simpler technique and resulted in comparable scars than W-pasty closure in this case series.

Different Clinicopathological Characteristics in Indonesian Colorectal Patients with NRAS Mutations and HER2 Over-Expression.

OBJECTIVE: This study aims to assess the association of subject characteristics and NRAS mutations with HER2 expression in CRC. METHODS: This research is a cross-sectional study. The research subjects in this study were colorectal cancer patients in the Digestive Surgery division at Dr. Hasan Sadikin Hospital. There were 58 study subjects. Examination of NRAS mutations was carried out by Polymerase Chain Reaction (PCR) from fresh tumour tissue obtained from surgery or colonoscopy. Meanwhile, HER2 examination used the Immunohistochemistry (IHC) method of paraffin blocks for anatomical pathology examination of the same patients. RESULT: HER2 overexpression was found in 6/58 (10.3%) patients with CRC, and from 8 subjects with NRAS mutations, only 1 subject (1.7%) showed overexpression of HER2. Univariate analysis of HER2 expression showed no significant associations to age, sex, histologic feature, tumor location, and NRAS mutations. A significant association was found between HER2 expression and stage of the CRC with p=0.001. CONCLUSION: There is no association between NRAS mutations and HER2 overexpression in colorectal cancer patients.